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How Fat is Stored and Used
When energy is excessive, it is converted into TGs and stored as fat in lipid droplets of adipocytes.
When energy is needed, these TGs are broken down into fatty acids and used as fuel.
Excess Fat : Causes and Consequences
Adipogenesis, lipogenesis, and appetite contribute to excess fat accumulation.
Excess fat accumulation can lead to obesity, insulin resistance, and chronic inflammation.
ACAT : Novel Target for Regulating Fat Growth
ACAT inhibition suppresses adipogenesis, lipogenesis, and appetite simultaneously.
Mode of Action
Zhu, Y. et at., Journal of Lipid Research, Vol. 59, Issue 5 (2018) and Liu, Q. et al., J Lipid Res Vol. 65, Issue 12 (2024)
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